多巴胺能神经元破坏会降低海马体中5-羟色胺1A受体对反式-[(18)F]米氮平的摄取。

Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[(18)F]Mefway.

作者信息

Lee Minkyung, Ryu Young Hoon, Cho Won Gil, Jeon Tae Joo, Lyoo Chul Hyoung, Kang Yeo Wool, Lee Soo Jin, Kim Chul Hoon, Kim Dong Goo, Kang Jee Hae, Seo Young Beom, Yi Chi Hoon, Lee Kyochul, Choi Tae Hyun, Choi Jae Yong

机构信息

Department of Nuclear Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 712, Eonjuro, Gangnam-Gu, Seoul 135-720, Republic of Korea.

Department of Anatomy, Yonsei University Wonju College of Medicine, Wonju 220-701, Republic of Korea.

出版信息

Appl Radiat Isot. 2014 Dec;94:30-34. doi: 10.1016/j.apradiso.2014.06.016. Epub 2014 Jul 8.

DOI:10.1016/j.apradiso.2014.06.016

PMID:25064461

Abstract

The purpose of the present study is to investigate the relationship between dopaminergic neuron destruction and 5-HT system changes in a hemiparkinsonian rat model. We performed PET imaging studies with trans-[(18)F]Mefway in a hemiparkinsonian model of unilateral 6-hydroxydopamine (6-OHDA) rats. Region-of-interests (ROIs) were drawn in the hippocampus (HP) and cerebellum (CB). HP uptake, the ratios of specific binding to non-specific binding in the HP, and non-displaceable binding potential (BPND) in the HP were compared between 6-OHDA and control rats. As a result, unilateral 6-OHDA-lesioned rats exhibited significant bilateral reduction of HP uptake and trans-[(18)F]Mefway BPND compared to the intact control group. Therefore, the results demonstrate that destruction of the dopaminergic system causes the reduction of the serotonergic system.

摘要

本研究的目的是探讨偏侧帕金森病大鼠模型中多巴胺能神经元破坏与5-羟色胺（5-HT）系统变化之间的关系。我们用反式-[(18)F]Mefway对单侧6-羟基多巴胺（6-OHDA）大鼠的偏侧帕金森病模型进行了正电子发射断层扫描（PET）成像研究。在海马体（HP）和小脑（CB）中绘制感兴趣区域（ROIs）。比较了6-OHDA大鼠和对照大鼠之间的HP摄取、HP中特异性结合与非特异性结合的比率以及HP中的不可置换结合潜能（BPND）。结果显示，与完整对照组相比，单侧6-OHDA损伤大鼠的HP摄取和反式-[(18)F]Mefway BPND出现显著的双侧降低。因此，结果表明多巴胺能系统的破坏会导致血清素能系统的减少。