Weintraub A S, Blanco V, Barnes M, Green R S
1] Mount Sinai Medical Center, Division of Newborn Medicine, Department of Pediatrics, Kravis Children's Hospital, New York, NY, USA [2] Department of Pediatrics, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Pediatrics, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
J Perinatol. 2015 Jan;35(1):52-6. doi: 10.1038/jp.2014.138. Epub 2014 Jul 31.
To examine the relationship between blood urea nitrogen (BUN) during the first 3 weeks of life and protein intake and creatinine (Cr) and to quantify the effect of protein intake on postnatal growth in preterm infants.
This is a 4-year, single-center, retrospective cohort study. We used multivariable linear regression models to examine the relationships between mean weekly BUN and protein intake adjusted for mean weekly Cr and potential confounders. We used additional regression models to examine the effect of protein intake on growth during this period.
Overall, 249 infants met study criteria. As protein intake increased over the first 3 weeks of life, both BUN and Cr decreased significantly. Linear regression models showed protein intake and Cr were each significantly associated with mean BUN for each study week.
Protein intake and Cr were each significantly associated with BUN. Significant amelioration of growth failure was seen with higher protein intake.
研究出生后3周内血尿素氮（BUN）与蛋白质摄入量、肌酐（Cr）之间的关系，并量化蛋白质摄入量对早产儿出生后生长的影响。
这是一项为期4年的单中心回顾性队列研究。我们使用多变量线性回归模型来研究平均每周BUN与经平均每周Cr及潜在混杂因素校正后的蛋白质摄入量之间的关系。我们使用额外的回归模型来研究此期间蛋白质摄入量对生长的影响。
总体而言，249名婴儿符合研究标准。在出生后的前3周内，随着蛋白质摄入量的增加，BUN和Cr均显著下降。线性回归模型显示，在每个研究周，蛋白质摄入量和Cr均与平均BUN显著相关。
蛋白质摄入量和Cr均与BUN显著相关。较高的蛋白质摄入量可显著改善生长发育不良的情况。
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