纤溶酶原激活物抑制剂-1基因4G/5G多态性和血管紧张素转换酶基因I/D多态性与复发性流产风险：一项病例对照研究。
The PAI-1 4G/5G and ACE I/D polymorphisms and risk of recurrent pregnancy loss: a case-control study.
作者信息
Kim Jin Ju, Choi Young Min, Lee Sung Ki, Yang Kwang Moon, Paik Eun Chan, Jeong Hyeon Jeong, Jun Jong Kwan, Han Ae Ra, Hong Min A
机构信息
Department of Obstetrics and Gynecology, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea; The Institute of Reproductive Medicine and Population, Medical Research Centre, Seoul National University College of Medicine, Seoul, Korea.
出版信息
Am J Reprod Immunol. 2014 Dec;72(6):571-6. doi: 10.1111/aji.12302. Epub 2014 Jul 31.
PROBLEM
Thrombophilia has been postulated to be a contributor to the pathophysiology of recurrent pregnancy loss (RPL). We investigated the role of the plasminogen activator inhibitor type 1 (PAI-1) 4G/5G and angiotensin converting enzyme (ACE) I/D polymorphisms in Korean patients with RPL.
METHOD OF STUDY
Genotyping was performed using the TaqMan assay in 227 RPL patients and 304 controls.
RESULTS
The genotype distributions of both polymorphisms in the RPL group did not differ from those of controls. Because the frequency of being homozygous for ACE D/D and the PAI-I 4G/4G combination has been reported to be significantly higher in RPL patients, this was also analyzed. However, no significant difference was noted; 3.1% of RPL patients had both ACE D/D and PAI-I 4G/4G, as did 4.9% of controls (P = 0.791).
CONCLUSION
The current study suggests that both polymorphisms, either alone or in combination, are not major determinants of the development of RPL in Korean women.
问题
血栓形成倾向被认为是复发性流产（RPL）病理生理学的一个促成因素。我们研究了纤溶酶原激活物抑制剂1型（PAI - 1）4G/5G和血管紧张素转换酶（ACE）I/D基因多态性在韩国RPL患者中的作用。
研究方法
采用TaqMan分析法对227例RPL患者和304例对照进行基因分型。
结果
RPL组中两种多态性的基因型分布与对照组无差异。由于据报道RPL患者中ACE D/D纯合子和PAI - I 4G/4G组合的频率显著更高，因此也对此进行了分析。然而，未观察到显著差异；3.1%的RPL患者同时具有ACE D/D和PAI - I 4G/4G，对照组为4.9%（P = 0.791）。
结论
当前研究表明，这两种多态性单独或联合起来都不是韩国女性RPL发生的主要决定因素。
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