关于7-氧代前列环素（7-oxo-PGI2）诱导的迟发性持久细胞保护作用。
On the 7-oxo-PGI2 induced late appearing long-lasting cytoprotective effect.
作者信息
Szekeres L, Bálint Z, Karcsu S, Tósaki A, Udvary E
机构信息
Institute of Pharmacology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
出版信息
Prog Clin Biol Res. 1989;301:143-7.
PMID:2508098
Abstract
Our results indicate that 7-oxo-PgI2 pretreatment may induce a long lasting cytoprotective effect by preventing ischemia induced intracellular potassium loss and sodium accumulation in myocardial cells of guinea pigs furthermore by protecting from ischemic ultrastructural changes as sarcomere shortening, mitochondrial swelling and irregularity of I, A and Z bands in the rabbit myocardium.
摘要
我们的结果表明，7-氧代前列环素I2预处理可能通过防止豚鼠心肌细胞缺血诱导的细胞内钾流失和钠蓄积，进而通过保护兔心肌免受缺血性超微结构变化（如肌节缩短、线粒体肿胀以及I、A和Z带不规则）的影响，诱导持久的细胞保护作用。
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