孕期叶酸浓度与后代自闭症特征。Generation R研究。
Folate concentrations during pregnancy and autistic traits in the offspring. The Generation R Study.
作者信息
Steenweg-de Graaff Jolien, Ghassabian Akhgar, Jaddoe Vincent W V, Tiemeier Henning, Roza Sabine J
机构信息
1 The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands 2 Department of Child and Adolescent Psychiatry/psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands.
1 The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands 3 Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands 4 Department of Paediatrics, Erasmus Medical Centre, Rotterdam, The Netherlands.
出版信息
Eur J Public Health. 2015 Jun;25(3):431-3. doi: 10.1093/eurpub/cku126. Epub 2014 Jul 31.
In a population-based study, we examined the associations of maternal plasma folate concentrations at 13 weeks of gestation and prenatal folic acid supplement use with autistic traits in the offspring at the age of six years. Parent-reported autistic traits were assessed using the Social Responsiveness Scale short form. Maternal folate was not associated with autistic traits in the offspring. In contrast, prenatal folic acid use was associated with less child autistic traits. Future research should focus on the timing of the potential effect of prenatal folate on the development of autistic traits in combination with clinical diagnosis of autism in the offspring.
在一项基于人群的研究中，我们考察了妊娠13周时母体血浆叶酸浓度和产前叶酸补充剂的使用与后代6岁时自闭症特征之间的关联。使用社会反应量表简表评估父母报告的自闭症特征。母体叶酸与后代自闭症特征无关。相比之下，产前使用叶酸与儿童自闭症特征较少有关。未来的研究应结合后代自闭症的临床诊断，关注产前叶酸对自闭症特征发展潜在影响的时机。
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