Institute of Biosciences and Technology, Texas A&M University Health Science Center , Houston, TX , USA ; Department of Medical Oncology, Affiliated Tumor Hospital of Harbin Medical University , Harbin , China.
Institute of Biosciences and Technology, Texas A&M University Health Science Center , Houston, TX , USA.
Front Immunol. 2014 Jul 23;5:352. doi: 10.3389/fimmu.2014.00352. eCollection 2014.
Prostate cancer is the second leading cause of cancer-related death in men after lung cancer. Immune responses clearly play a critical role in the tumorigenesis and in the efficacy of radiation therapy and chemotherapy in prostate cancer; however, the underlying molecular mechanisms are still poorly understood. Toll-like receptors (TLRs) are a well-known family of pattern recognition receptors that play a key role in host immune system. Recent studies demonstrate that there are links between TLRs and cancer; however, the function and biological importance of TLRs in prostate cancer seems complex. To elucidate the role of TLRs and innate immunity in prostate cancer might provide us with a better understanding of the molecular mechanisms of this disease. Moreover, utilizing the agonists or antagonists of TLRs might represent a promising new strategy against prostate cancer. In this review, we summarize recent advances on the studies of association between TLR signaling and prostate cancer, TLR polymorphisms and prostate cancer risk, and provide some insights about TLRs as potential targets for prostate cancer immunotherapy.
前列腺癌是继肺癌之后导致男性癌症相关死亡的第二大主要原因。免疫反应显然在前列腺癌的肿瘤发生以及放射治疗和化学疗法的疗效中发挥着关键作用；然而，其潜在的分子机制仍知之甚少。Toll 样受体 (TLR) 是一个众所周知的模式识别受体家族，在宿主免疫系统中发挥着关键作用。最近的研究表明，TLR 与癌症之间存在联系；然而，TLR 在前列腺癌中的功能和生物学重要性似乎很复杂。阐明 TLR 和先天免疫在前列腺癌中的作用可能使我们更好地了解该疾病的分子机制。此外，利用 TLR 的激动剂或拮抗剂可能代表针对前列腺癌的一种有前途的新策略。在这篇综述中，我们总结了 TLR 信号与前列腺癌之间关联、TLR 多态性与前列腺癌风险的研究进展，并探讨了 TLR 作为前列腺癌免疫治疗潜在靶点的可能性。
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