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[细胞黄素和心磷脂对血脂异常大鼠血液中脂质过氧化指标和抗氧化保护的影响]

[The influence of cytoflavin and cardioxipin on the indices of lipid peroxidation and antioxidant protection in the blood of rat with dyslipidemia].

作者信息

Vodop'ianova O A, Moiseeva I Ia, Rodina O P, Kustikova I N, Antropova N V

出版信息

Eksp Klin Farmakol. 2014;77(6):27-9.

Abstract

Comparative tests on nonlinear rats of both sex with model violation of lipid metabolism have been performed in order to study the effects of cytoflavin (1.75 ml/kg or 175 mg/kg with respect to succinic acid) and cardioxipin (52.5 mg/kg) on lipid peroxidation and antioxidant protection indices in the blood. It is established that these preparations cause a decrease in the content of malonic dialdehyde (MDA) in erythrocytes that results in increased antioxidant activity and lipid reserves for peroxidation in the blood.

摘要

为研究细胞黄素(相对于琥珀酸为1.75毫升/千克或175毫克/千克)和心磷脂(52.5毫克/千克)对脂质代谢模型异常的雌雄非线性大鼠血液中脂质过氧化和抗氧化保护指标的影响,进行了对比试验。结果表明,这些制剂可使红细胞中丙二醛(MDA)含量降低,从而提高抗氧化活性并增加血液中脂质过氧化的储备。

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