希腊一名16个月大儿童感染人恋群球菌序列型复合群14引发的关节炎。

Kingella kingae sequence type-complex 14 arthritis in a 16-month-old child in Greece.

作者信息

Grivea Ioanna N, Michoula Aspasia N, Basmaci Romain, Dailiana Zoe H, Tsimitselis George, Bonacorsi Stéphane, Syrogiannopoulos George A

机构信息

From the *Departments of Pediatrics, University of Thessaly, School of Health Sciences, Faculty of Medicine, General University Hospital, Larissa, Greece; †Univ Paris Diderot, Sorbonne Paris Cité; ‡AP-HP, Laboratoire de Microbiologie, Hôpital Robert-Debré, Paris, France; Departments of §Orthopedic Surgery; and ¶Radiology, University of Thessaly, School of Health Sciences, Faculty of Medicine, General University Hospital, Larissa, Greece.

出版信息

Pediatr Infect Dis J. 2015 Jan;34(1):107-8. doi: 10.1097/INF.0000000000000503.

DOI:10.1097/INF.0000000000000503

PMID:25105896

Abstract

We describe the first case of Kingella kingae arthritis in a 16-month-old girl in Greece, which has been diagnosed by novel molecular techniques. A joint aspiration of her knee was performed before the initiation of antibiotics, as well as on the 5th and 14th day of empiric antimicrobial therapy. The synovial fluid white blood cell count decreased from 65,000 to 1500 cells/mm, but the percentage of neutrophils remained 90% in all 3 specimens. Molecular analysis of the synovial fluid specimens by real-time polymerase chain reaction and multilocus sequence typing enabled us to reveal the presence of K. kingae belonging to the international sequence type-complex 14, which persisted up to the fifth day of antibiotic therapy.

摘要

我们描述了希腊一名16个月大女童患金氏金杆菌关节炎的首例病例，该病例通过新型分子技术得以诊断。在使用抗生素之前以及经验性抗菌治疗的第5天和第14天，对她的膝盖进行了关节穿刺。滑液白细胞计数从65,000降至1500个细胞/mm，但在所有3份标本中，中性粒细胞百分比均保持在90%。通过实时聚合酶链反应和多位点序列分型对滑液标本进行分子分析，使我们能够揭示属于国际序列型复合体14的金氏金杆菌的存在，该菌在抗生素治疗的第5天仍持续存在。