Gupta Ajay
Department of Pediatric Epilepsy/Epilepsy Center-S51, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA,
Indian J Pediatr. 2014 Oct;81(10):1081-8. doi: 10.1007/s12098-014-1541-1. Epub 2014 Aug 14.
Epilepsy surgery is safe and effective treatment in children who fail to respond to antiepileptic medications. After failure of two appropriate antiepileptic medications, chances that the child will become seizure free with more or different medications is <5%, and she should be diagnosed with "refractory epilepsy". A consideration for surgical candidacy should be given to all children who fulfill the definition of refractory epilepsy. In appropriately selected children, epilepsy surgery offers a high chance of seizure freedom without incurring any new post-operative neurological deficits. No age is bar to epilepsy surgery. Even infants can safely have epilepsy surgery if they are surgical candidates. For most children, who are surgical candidates, a good history and physical examination, video EEG evaluation, and a high quality brain MRI are sufficient to make surgical decision. These tools are increasingly available all over the world. Better education of families, Pediatricians, Pediatric Neurologists and community care-givers is necessary to salvage children early from mortality and morbidity of untreated, sometimes life long, epilepsy.
对于对抗癫痫药物无反应的儿童,癫痫手术是一种安全有效的治疗方法。在两种合适的抗癫痫药物治疗失败后,儿童通过更多或不同药物实现无癫痫发作的几率小于5%,此时应诊断为“难治性癫痫”。所有符合难治性癫痫定义的儿童都应考虑是否适合手术治疗。在适当选择的儿童中,癫痫手术有很高的几率使癫痫发作停止,且不会产生任何新的术后神经功能缺损。癫痫手术没有年龄限制。即使是婴儿,如果他们是手术候选人,也可以安全地进行癫痫手术。对于大多数适合手术的儿童,详细的病史和体格检查、视频脑电图评估以及高质量的脑部核磁共振成像足以做出手术决策。这些工具在世界各地越来越普及。有必要更好地教育家庭、儿科医生、儿科神经科医生和社区护理人员,以便尽早将儿童从未经治疗的、有时是终生的癫痫所带来的死亡和发病风险中拯救出来。