[小儿多发伤中的生物标志物]
[Biomarkers in pediatric polytrauma].
作者信息
Andruszkow H, Pfeifer R, Horst K, Kobbe P, Pape H-C, Hildebrand F
机构信息
Klinik für Unfall- und Wiederherstellungschirurgie und Harald Tscherne Forschungslabor, Universitätsklinikum der RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland,
出版信息
Unfallchirurg. 2014 Aug;117(8):679-85. doi: 10.1007/s00113-013-2541-8.
BACKGROUND
Trauma represents one of the leading causes of death in children. Beside an injury pattern that differs from adult trauma patients, children seem to develop multiple organ dysfunction syndrome (MODS) less frequently. Compared to adult MODS, pediatric MODS has also been described to occur earlier in the posttraumatic course.
METHOD
Biomarkers for early identification of patients at high-risk for posttraumatic complications are of high clinical relevance. However, little is known from clinical studies about the relevance of biomarkers during the posttraumatic course.
AIM
Therefore, the purpose of this review is to summarize current knowledge on this topic in order to investigate the prognostic significance of different parameters.
背景
创伤是儿童死亡的主要原因之一。除了损伤模式与成人创伤患者不同外，儿童似乎较少发生多器官功能障碍综合征（MODS）。与成人MODS相比，小儿MODS也被描述为在创伤后病程中出现得更早。
方法
用于早期识别创伤后并发症高危患者的生物标志物具有很高的临床相关性。然而，临床研究对创伤后病程中生物标志物的相关性了解甚少。
目的
因此，本综述的目的是总结该主题的现有知识，以研究不同参数的预后意义。
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