有氧铜催化导向芳环/炔烃环化反应。

Directed arene/alkyne annulation reactions via aerobic copper catalysis.

机构信息

Key Laboratory of Chemical Genomics, Peking University, Shenzhen Graduate School, Shenzhen 518055, China.

出版信息

Org Biomol Chem. 2014 Nov 28;12(44):8844-50. doi: 10.1039/c4ob01312c.

Abstract

We describe a straightforward protocol for a smooth dehydrogenative annulation reaction between various arenes and terminal alkynes using a catalytic amount of CuBr2 and molecular oxygen. 3-Methyleneisoindoline derivatives are prepared in high yields.

摘要

我们描述了一种使用催化量的 CuBr2 和分子氧实现各种芳基和末端炔烃之间脱氢环化反应的简单方法。高收率制备了 3-亚甲基异吲哚啉衍生物。