Beyazyıldız Emrullah, Beyazyıldız Ozlem, Arifoğlu Hasan Basri, Altıntaş Ayşegül Koçak, Köklü Sükrü Gültekin
Department of Ophthalmology, Gazi Mustafa Kemal State Hospital, Ankara, Turkey.
Indian J Ophthalmol. 2014 Jul;62(7):782-7. doi: 10.4103/0301-4738.138180.
We sought to identify differences in the following measures of the ocular response analyser (ORA) between primary open angle glaucoma (POAG) and exfoliative glaucoma (EXG) patients: Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc) and Goldmann-correlated intraocular pressure (IOPg). We also sought to relate these ORA measures with central corneal thickness (CCT).
This cross-sectional study was conducted on a total of 162 individuals (46 EXG patients, 66 POAG patients and 50 healthy subjects without any ocular and systemic disease). ORA measurements were performed, and a minimum of three readings were obtained from each test subject. Groups were compared according to their ORA parameters.
The mean CH levels of the EXG, POAG and healthy subjects were 7.6 ± 2.1, 9.1 ± 1.9 and 9.6 ± 1.7 mmHg, respectively. CH was significantly lower in the EXG patients compared to the other groups (P < 0.001).The mean CRF levels of the EXG, POAG and healthy subjects were 9.0 ± 2.0, 10.1 ± 1.7 and 9.8 ± 1.8mmHg, respectively. CRF levels in the eyes of the EXG patients were significantly lower compared to those of either the POAG patients (P = 0.005) or the healthy subjects (P = 0.03), but there was no significant difference in CRF levels between the POAG patients and the healthy subjects (P = 0.59). There was a significant positive correlation between CH and CCT in the EXG patients and healthy subjects (P < 0.001), but this correlation was not present in the POAG patients (P = 0.70).
In this study, CH and CRF were found to be significantly reduced in the eyes of EXG patients compared to both the POAG patients and healthy subjects. Reduced CH in EXG patients might result in decreased support of peripapillary scleral structure and increased damage to the optic nerve during IOP increase.
我们试图确定原发性开角型青光眼(POAG)和剥脱性青光眼(EXG)患者在眼反应分析仪(ORA)以下各项测量指标上的差异:角膜滞后(CH)、角膜阻力因子(CRF)、角膜补偿眼压(IOPcc)和戈德曼相关眼压(IOPg)。我们还试图将这些ORA测量指标与中央角膜厚度(CCT)联系起来。
本横断面研究共纳入162名个体(46例EXG患者、66例POAG患者和50名无任何眼部及全身疾病的健康受试者)。进行了ORA测量,每个受试对象至少获得三次读数。根据ORA参数对各组进行比较。
EXG患者、POAG患者和健康受试者的平均CH水平分别为7.6±2.1、9.1±1.9和9.6±1.7mmHg。与其他组相比,EXG患者的CH显著降低(P<0.001)。EXG患者、POAG患者和健康受试者的平均CRF水平分别为9.0±2.0、10.1±1.7和9.8±1.8mmHg。EXG患者眼中的CRF水平显著低于POAG患者(P = 0.005)或健康受试者(P = 0.03),但POAG患者和健康受试者之间的CRF水平无显著差异(P = 0.59)。EXG患者和健康受试者中CH与CCT之间存在显著正相关(P<0.001),但POAG患者中不存在这种相关性(P = 0.70)。
在本研究中,发现EXG患者眼中的CH和CRF与POAG患者和健康受试者相比均显著降低。EXG患者CH降低可能导致视乳头周围巩膜结构支撑减少,眼压升高期间视神经损伤增加。