Cepeda M Soledad, Fife Daniel, Berwaerts Joris, Yuan Yingli, Mastrogiovanni Greg
Janssen Research & Development, LLC, 1125 Trenton Harbourton Rd, Titusville, NJ, 08560, USA,
Drugs R D. 2014 Sep;14(3):205-11. doi: 10.1007/s40268-014-0058-4.
Attention-deficit hyperactivity disorder (ADHD) medications are subject to abuse, misuse, and diversion. Obtaining ADHD prescriptions from multiple prescribers or filled across multiple pharmacies, known as 'doctor shopping', may reflect such unsanctioned use. We sought to create a definition of shopping behavior that differentiated ADHD medications from medications with low risk of diversion, i.e. asthma medications, and describe the incidence, frequency, and demography of shopping behavior.
This was a retrospective cohort study in a pharmacy database-LRx-covering 65 % of US retail pharmacies. Subjects had ADHD or asthma medication dispensed between February 2011 and January 2012. We followed subjects for 18 months to assess the number with overlapping dispensings from different prescribers, and the number of prescribers and pharmacies involved in those dispensings.
We included 4,402,464 subjects who were dispensed ADHD medications, and 6,128,025 subjects who were dispensed asthma medications. Overlapping prescriptions from two or more prescribers dispensed by three or more pharmacies was four times more frequent in the ADHD cohort than in the asthma cohort. Using this definition, ADHD medication shopping behavior was more common among experienced users than naïve users, and was most common in subjects aged 10-39 years. Among subjects who shopped, 57.4 % shopped only once (accounting for 22.4 % of episodes), and 9.2 % shopped six or more times (accounting for 42.0 % of episodes). Shoppers more often received stimulant ADHD drugs than non-stimulants.
Overlapping prescriptions by different prescribers and filled at three or more pharmacies defines ADHD medication shopping. Shopping behavior is most common in adolescents and younger adults. A small proportion of shoppers is responsible for a large number of shopping episodes.
注意力缺陷多动障碍(ADHD)药物存在滥用、误用和转移用途的情况。从多个开处方者处获取ADHD处方或在多个药房配药,即所谓的“医生购物”,可能反映了这种未经许可的使用情况。我们试图创建一种购物行为的定义,以区分ADHD药物与转移用途风险较低的药物,即哮喘药物,并描述购物行为的发生率、频率和人口统计学特征。
这是一项在药房数据库LRx中进行的回顾性队列研究,该数据库覆盖了美国65%的零售药房。研究对象在2011年2月至2012年1月期间配过ADHD或哮喘药物。我们对研究对象进行了18个月的跟踪,以评估从不同开处方者处重叠配药的人数,以及参与这些配药的开处方者和药房的数量。
我们纳入了4402464名配过ADHD药物的研究对象和6128025名配过哮喘药物的研究对象。由三个或更多药房调配的来自两个或更多开处方者的重叠处方在ADHD队列中的出现频率是哮喘队列中的四倍。根据这个定义,ADHD药物购物行为在有经验的使用者中比新手使用者中更常见,并且在10至39岁的研究对象中最为常见。在进行购物行为的研究对象中,57.4%只购物过一次(占事件的22.4%),9.2%购物过六次或更多次(占事件的42.0%)。购物者比非购物者更常接受刺激性ADHD药物。
由不同开处方者开出并在三个或更多药房配药的重叠处方定义了ADHD药物购物行为。购物行为在青少年和年轻成年人中最为常见。一小部分购物者导致了大量的购物事件。