Atiba A S, Abbiyesuku F M, Adekanle D A, Oparinde D P, Ajose O A, Niran-Atiba T A
Department of Chemical Pathology, Ekiti State University, Ado-Ekiti, Nigeria.
Niger Postgrad Med J. 2014 Jun;21(2):150-4.
To determine changes in malondialdehyde (product of lipid peroxidation) and antioxidant enzymes (Superoxide Dismutase, Glutathione Per-oxidase) levels in pre-eclamptic Nigerian women
A Total of 100 subjects each for pre-eclamptic,apparently normal and non pregnant women were recruited into the study.Venous blood samples were taken from the participants during second and third trimesters of pregnancy and at the point of contact for non pregnant women. Malondialdehyde, glutathione peroxidase and superoxide dismutase were measured accordingly from plasma and haemolysate prepared from whole blood.Variables were analysed using SPSS version 16, taking level of significance to be 0.05 RESULTS: Plasma malondialdehyde in the third trimester (3.13±0.61umol/l) of pre-eclamptic subjects was higher than in the second trimester (3.00±1.21umol/l).Plasma malondialdehyde in the third trimester of normal pregnancy (2.03±0.71umol/l) was also found to be significantly higher than in the second trimester (1.65±0.62umol/ l)(p<0.0001). Glutathione peroxidase in pre-eclamptic subjects was significantly higher in the third trimester (2804.11±1573.00U/L) as compared to the second trimester (2655.00±1751.30U/L), p= 0.0001.Glutathione peroxidase activity in the third trimester of normal pregnancy(3339.50±1733.80U/L) was also found to be higher than in the second trimester(3023.50±1115.90U/L)(p=0.131). Superoxide dismutase activity was significantly lower in the third trimester of pre-eclamptic pregnancy when compared to second trimester (110.40±59.47 Vs 118.01±64.41 U/ ml)(p<0.039) .Similarly,superoxide dismutase activity was significantly lower in the third trimester of normal pregnancy (110.40±59.47U/ml) than in the second trimester(153.01±71.85U/ml)(p<0.0001).
There was an increased level of lipid peroxidation products,malondialdehyde in subjects with pre-eclampsia. This was more in the third trimester. There was an increased oxidative stress in pre-eclampsia as evidenced also by low serum level of superoxide dismutase in the third trimester.Diet rich in antioxidant enzyme might be beneficial.
测定尼日利亚先兆子痫妇女体内丙二醛（脂质过氧化产物）和抗氧化酶（超氧化物歧化酶、谷胱甘肽过氧化物酶）水平的变化
共招募100名先兆子痫患者、外表正常的孕妇及未孕女性作为研究对象。在妊娠中期和晚期采集参与者的静脉血样本，未孕女性则在接触时采集。分别从血浆和全血制备的溶血产物中测定丙二醛、谷胱甘肽过氧化物酶和超氧化物歧化酶。使用SPSS 16版软件分析变量，显著性水平设定为0.05。结果：先兆子痫患者妊娠晚期血浆丙二醛水平（3.13±0.61umol/l）高于妊娠中期（3.00±1.21umol/l）。正常妊娠晚期血浆丙二醛水平（2.03±0.71umol/l）也显著高于妊娠中期（1.65±0.62umol/l）（p<0.0001）。先兆子痫患者谷胱甘肽过氧化物酶在妊娠晚期（2804.11±1573.00U/L）显著高于妊娠中期（2655.00±1751.30U/L），p = 0.0001。正常妊娠晚期谷胱甘肽过氧化物酶活性（3339.50±1733.80U/L）也高于妊娠中期（3023.50±1115.90U/L）（p = 0.131）。先兆子痫妊娠晚期超氧化物歧化酶活性显著低于妊娠中期（110.40±59.47对118.01±64.41U/ml）（p<0.039）。同样，正常妊娠晚期超氧化物歧化酶活性（110.40±59.47U/ml）显著低于妊娠中期（153.01±71.85U/ml）（p<0.0001）。
先兆子痫患者脂质过氧化产物丙二醛水平升高，在妊娠晚期更为明显。先兆子痫存在氧化应激增加，妊娠晚期血清超氧化物歧化酶水平降低也证明了这一点。富含抗氧化酶的饮食可能有益。
Zotero 插件