弥漫性实质性肺淀粉样变性对基于硼替佐米的化疗表现出客观反应。

Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy.

作者信息

Higo Hisao, Fujiwara Keiichi, Watanabe Hiromi, Makimoto Go, Kameyama Nobuhisa, Matsushita Mizuho, Rai Kammei, Sato Ken, Inomata Tomoko, Sunami Kazutaka, Shibayama Takuo

机构信息

Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.

出版信息

Intern Med. 2014;53(16):1809-12. doi: 10.2169/internalmedicine.53.1728. Epub 2014 Aug 15.

DOI:10.2169/internalmedicine.53.1728

PMID:25130116

Abstract

A 77-year-old woman was admitted because of bilateral hand numbness and dyspnea on exertion. Her serum IgG was increased, and a bone marrow aspiration analysis supported a diagnosis of multiple myeloma. Additionally, computed tomography scans of the chest showed bilateral ground glass attenuations, linear opacities, and consolidations. Transbronchial lung biopsy revealed Congo Red-positive amorphous eosinophilic deposits. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by multiple myeloma. Following combination chemotherapy including bortezomib, her serum monoclonal protein levels were normalized, and pulmonary function and oxygenation improved.

摘要

一名77岁女性因双侧手部麻木和劳力性呼吸困难入院。她的血清IgG升高，骨髓穿刺分析支持多发性骨髓瘤的诊断。此外，胸部计算机断层扫描显示双侧磨玻璃影、线状阴影和实变。经支气管肺活检显示刚果红阳性无定形嗜酸性沉积物。因此，她被诊断为弥漫性实质性肺淀粉样变合并多发性骨髓瘤。在接受包括硼替佐米在内的联合化疗后，她的血清单克隆蛋白水平恢复正常，肺功能和氧合改善。