富集的 CD44(+)/CD24(-) 群体驱动三阴性乳腺癌 (TNBC) 中呈现的侵袭表型。
Enriched CD44(+)/CD24(-) population drives the aggressive phenotypes presented in triple-negative breast cancer (TNBC).
机构信息
Department of Medical Oncology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Shandong Cancer Hospital/Institute, Jinan, Shandong 250017, China.
出版信息
Cancer Lett. 2014 Oct 28;353(2):153-9. doi: 10.1016/j.canlet.2014.06.022. Epub 2014 Aug 14.
The mechanism underlying the aggressive behaviors of triple negative breast cancer (TNBC) is not well characterized yet. The association between cancer stem cell (CSC) population and the aggressive behaviors of TNBC has not been established. We found the CD44(+)/CD24(-) cell population was enriched in TNBC tissues and cell lines, with a higher capacity of proliferation, migration, invasion and tumorigenicity as well as lower adhesion ability. The CD44(+)/CD24(-) cell population with cancer stem cell-like properties may play an important role in the aggressive behaviors of TNBC. This discovery may lead to new therapeutic strategies targeting CD44(+)/CD24(-) cell population in TNBC.
三阴性乳腺癌（TNBC）侵袭性行为的潜在机制尚未完全阐明。癌症干细胞（CSC）群体与 TNBC 侵袭性行为之间的关联尚未确定。我们发现 CD44(+)/CD24(-) 细胞群体在 TNBC 组织和细胞系中富集，具有更高的增殖、迁移、侵袭和致瘤能力，以及更低的黏附能力。具有癌症干细胞样特性的 CD44(+)/CD24(-) 细胞群体可能在 TNBC 的侵袭性行为中发挥重要作用。这一发现可能为针对 TNBC 中 CD44(+)/CD24(-) 细胞群体的新治疗策略提供依据。
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