一种用于开发基于锆-89的稳定分子成像探针的八齿双功能螯合剂。
An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes.
作者信息
Patra Malay, Bauman Andreas, Mari Cristina, Fischer Christiane A, Blacque Olivier, Häussinger Daniel, Gasser Gilles, Mindt Thomas L
机构信息
Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
出版信息
Chem Commun (Camb). 2014 Oct 9;50(78):11523-5. doi: 10.1039/c4cc05558f.
(89)Zr-based imaging agents hold great promise as novel radio-tracers in nuclear medicine. However, insufficient stability of currently used radiometal complexes in vivo is a safety concern for clinical applications. We herein report the first octadentate bifunctional chelating agent for the development of (89)Zr-labelled (bio)conjugates with improved stability.
基于锆-89的显像剂作为核医学中的新型放射性示踪剂具有巨大潜力。然而，目前使用的放射性金属络合物在体内稳定性不足，这是临床应用中的一个安全问题。我们在此报告了第一种用于开发具有更高稳定性的锆-89标记（生物）共轭物的八齿双功能螯合剂。
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