高剂量外用夫西地酸和夫西地酸耐药金黄色葡萄球菌的快速克隆扩张：一个警示故事。
High usage of topical fusidic acid and rapid clonal expansion of fusidic acid-resistant Staphylococcus aureus: a cautionary tale.
机构信息
Department of Molecular Medicine and Pathology, University of Auckland Institute of Environmental Science and Research, Wellington Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.
Alere Technologies, Jena Institute for Medical Microbiology and Hygiene, Dresden, Germany.
出版信息
Clin Infect Dis. 2014 Nov 15;59(10):1451-4. doi: 10.1093/cid/ciu658. Epub 2014 Aug 18.
Our aim was to assess national prescribing trends and determine longitudinal resistance patterns for topical antimicrobials in New Zealand. We observed a dramatic increase in fusidic acid (FA) resistance, and clonal expansion of FA-resistant Staphylococcus aureus. This increase was concurrent with a significant national increase in topical FA dispensing.
我们的目的是评估新西兰局部抗菌药物的国家处方趋势，并确定其耐药性的纵向变化模式。我们观察到，在新西兰，夫西地酸（FA）耐药性显著增加，且对夫西地酸耐药的金黄色葡萄球菌发生了克隆扩张。这种增加与局部夫西地酸配药的全国性显著增加同时发生。
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