分子成像在深静脉血栓形成诊断中的作用。
The role of molecular imaging in diagnosis of deep vein thrombosis.
作者信息
Houshmand Sina, Salavati Ali, Hess Søren, Ravina Mudalsha, Alavi Abass
机构信息
Department of Radiology, University of Pennsylvania Philadelphia, USA.
Department of Nuclear Medicine, Odense University Hospital Denmark.
出版信息
Am J Nucl Med Mol Imaging. 2014 Aug 15;4(5):406-25. eCollection 2014.
Abstract
Venous thromboembolism (VTE) mostly presenting as deep venous thrombosis (DVT) and pulmonary embolism (PE) affects up to 600,000 individuals in United States each year. Clinical symptoms of VTE are nonspecific and sometimes misleading. Additionally, side effects of available treatment plans for DVT are significant. Therefore, medical imaging plays a crucial role in proper diagnosis and avoidance from over/under diagnosis, which exposes the patient to risk. In addition to conventional structural imaging modalities, such as ultrasonography and computed tomography, molecular imaging with different tracers have been studied for diagnosis of DVT. In this review we will discuss currently available and newly evolving targets and tracers for detection of DVT using molecular imaging methods.
摘要
静脉血栓栓塞症（VTE）主要表现为深静脉血栓形成（DVT）和肺栓塞（PE），在美国每年影响多达60万人。VTE的临床症状不具特异性，有时还会产生误导。此外，现有DVT治疗方案的副作用很大。因此，医学成像在正确诊断以及避免过度/漏诊方面起着至关重要的作用，过度/漏诊会使患者面临风险。除了传统的结构成像方式，如超声检查和计算机断层扫描外，人们还研究了使用不同示踪剂的分子成像来诊断DVT。在本综述中，我们将讨论目前可用的以及新出现的用于通过分子成像方法检测DVT的靶点和示踪剂。
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