NEW BASE-ALTERED ADENOSINE ANALOGUES: SYNTHESIS AND AFFINITY AT ADENOSINE A and A RECEPTORS.
作者信息
Ha Seung B, Melman Neli, Jacobson Kenneth A, Nair Vasu
机构信息
Department of Chemistry, The University of Iowa, Iowa City, Iowa 52242, U.S.A.
Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892, U.S.A.
出版信息
Bioorg Med Chem Lett. 1997 Dec 16;7(24):3085-3090. doi: 10.1016/S0960-894X(97)10177-9.
Abstract
N-Substituted adenosine analogues containing cyclic hydrazines or chiral hydroxy (ar)alkyl groups, designed to interact with the S2 and S3 receptor subregions, have been synthesized and their binding to the adenosine A and A receptors have been investigated. Examples of both types of compounds were found to exhibit highly selective binding (K in low nM range) to the rat A receptor.
摘要
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