Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Italy.
Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Italy.
Photodiagnosis Photodyn Ther. 2014 Dec;11(4):516-8. doi: 10.1016/j.pdpdt.2014.08.002. Epub 2014 Aug 21.
Ulcerative necrobiosis lipoidica (NL) is a rare skin condition refractory to conventional therapies. We treated a forty-four year old woman affected by widespread ulcerative NL with 6 sessions of topical ALA-PDT at two weeks intervals. At the end of the treatment a dramatic improvement of the clinical features was observed, with complete healing of cutaneous ulcers and marked reduction of erythema in all the treated areas. The mechanism of action of PDT in ulcer healing is still unknown; however, it is possible to hypothesize a combination of anti-inflammatory effect, immunomodulatory activity and keratinocytes photoactivation.
溃疡性脂性坏死（NL）是一种罕见的皮肤疾病，对常规治疗有抗性。我们用 6 个疗程的局部 5-氨基酮戊酸光动力疗法（ALA-PDT），每两周一次，治疗了一位 44 岁的广泛性溃疡性 NL 女性患者。在治疗结束时，观察到临床症状显著改善，所有治疗区域的皮肤溃疡完全愈合，红斑明显减少。PDT 在溃疡愈合中的作用机制尚不清楚；然而，可以假设其具有抗炎作用、免疫调节活性和角质形成细胞光激活的综合作用。
