紧密连接与基因表达的调控

Tight junctions and the regulation of gene expression.

作者信息

González-Mariscal Lorenza, Domínguez-Calderón Alaide, Raya-Sandino Arturo, Ortega-Olvera José Mario, Vargas-Sierra Orlando, Martínez-Revollar Gabriela

机构信息

Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, México, D.F., Mexico.

出版信息

Semin Cell Dev Biol. 2014 Dec;36:213-23. doi: 10.1016/j.semcdb.2014.08.009. Epub 2014 Aug 23.

DOI:10.1016/j.semcdb.2014.08.009

PMID:25152334

Abstract

Tight junctions (TJ) regulate the paracellular passage of ions and molecules through the paracellular pathway and maintain plasma membrane polarity in epithelial and endothelial cells. Apart from these canonical functions, several proteins of the TJ have been found in recent years to regulate gene expression. This function is found in proteins that shuttle between the nucleus and TJs, and in integral TJ proteins. In this review, we will describe these proteins and their known mechanisms of gene regulation.

摘要

紧密连接（TJ）通过细胞旁途径调节离子和分子的细胞旁转运，并维持上皮细胞和内皮细胞的质膜极性。除了这些经典功能外，近年来还发现紧密连接的几种蛋白质可调节基因表达。在穿梭于细胞核和紧密连接之间的蛋白质以及完整的紧密连接蛋白质中发现了这种功能。在这篇综述中，我们将描述这些蛋白质及其已知的基因调控机制。