金属感知的特异性：枯草芽孢杆菌中的铁和锰稳态
Specificity of metal sensing: iron and manganese homeostasis in Bacillus subtilis.
作者信息
Helmann John D
机构信息
From the Department of Microbiology, Cornell University, Ithaca, New York 14853-8101
出版信息
J Biol Chem. 2014 Oct 10;289(41):28112-20. doi: 10.1074/jbc.R114.587071. Epub 2014 Aug 26.
Abstract
Metalloregulatory proteins allow cells to sense metal ions and appropriately adjust the expression of metal uptake, storage, and efflux pathways. Bacillus subtilis provides a model for the coordinate regulation of iron and manganese homeostasis that involves three key regulators: Fur senses iron sufficiency, MntR senses manganese sufficiency, and PerR senses the intracellular Fe/Mn ratio. Here, I review the structural and physiological bases of selective metal perception, the effects of non-cognate metals, and mechanisms that may serve to coordinate iron and manganese homeostasis.
摘要
金属调节蛋白使细胞能够感知金属离子，并相应地调节金属摄取、储存和外排途径的表达。枯草芽孢杆菌为铁和锰稳态的协调调节提供了一个模型，该模型涉及三个关键调节因子：Fur感知铁的充足程度，MntR感知锰的充足程度，PerR感知细胞内铁/锰比例。在此，我综述了选择性金属感知的结构和生理基础、非同源金属的影响以及可能用于协调铁和锰稳态的机制。
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