非阿尔茨海默型神经退行性痴呆：临床及18F-FDG-PET/CT影像表现

Non-Alzheimer types of neurodegenerative dementia: clinical and 18F-FDG-PET/CT pictures.

作者信息

Grassetto Gaia, Marzola Maria Cristina, Musto Alessandra, Viniamury Sobhan, Colletti Patrick M, Perkins Alan C, Rubello Domenico

机构信息

aNuclear Medicine Department, Santa Maria della Misericordia Hospital, Rovigo bNuclear Medicine Department, Maggiore Hospital, Bologna, Italy cNuclear Medicine Department, Royal Liverpool and Broadgreen University, Hospitals NHS Trust, Liverpool dDepartment of Physics, University of Nottingham, Nottingham, UK eDepartment of Radiology, University of Southern California, Los Angeles, California, USA.

出版信息

Nucl Med Commun. 2014 Nov;35(11):1085-92. doi: 10.1097/MNM.0000000000000191.

DOI:10.1097/MNM.0000000000000191

PMID:25162962

Abstract

Primary degenerative dementia syndromes are an increasingly relevant problem worldwide because of the progressive aging of the population. Their diagnosis is often a challenge for clinicians and, even in the best cases, only a possible or probable diagnosis can be reached. Molecular neuroimaging techniques can be very useful in dementia patients, especially for obtaining a diagnosis in the early stage of disease. The most diffuse and widely available nuclear medicine method for neurological studies is F-fluoro-deoxy-glucose (F-FDG)-PET, which allows the quantification of glucose gray matter metabolism and helps visualize typical, adequately specific, patterns for many kinds of degenerative dementia, not only for the well-known and well-studied Alzheimer's disease. This paper aims to describe the clinical and F-FDG-PET profiles of the principal non-Alzheimer type of degenerative dementias.

摘要

由于人口的逐渐老龄化，原发性退行性痴呆综合征在全球范围内已成为一个日益重要的问题。对临床医生而言，其诊断往往是一项挑战，即便在最佳情况下，也只能得出可能或很可能的诊断。分子神经影像学技术对痴呆患者可能非常有用，尤其是在疾病早期进行诊断时。用于神经学研究的最普及且应用广泛的核医学方法是氟脱氧葡萄糖（F-FDG）正电子发射断层扫描（PET），它能够对葡萄糖灰质代谢进行定量分析，并有助于呈现多种退行性痴呆典型且具有足够特异性的模式，不仅适用于广为人知且研究充分的阿尔茨海默病。本文旨在描述主要的非阿尔茨海默型退行性痴呆的临床和F-FDG-PET特征。