用于诊断慢性复发性多灶性骨髓炎的99mTc-HMPAO标记白细胞扫描

99mTc-HMPAO-labeled WBC scan for the diagnosis of chronic recurrent multifocal osteomyelitis.

作者信息

Dailey Tyler A, Berven Michael D, Vroman Penny J

机构信息

Department of Radiology, San Antonio Military Medical Center, Fort Sam Houston, Texas

Department of Radiology, San Antonio Military Medical Center, Fort Sam Houston, Texas.

出版信息

J Nucl Med Technol. 2014 Dec;42(4):299-301. doi: 10.2967/jnmt.114.138073. Epub 2014 Aug 28.

DOI:10.2967/jnmt.114.138073

PMID:25168250

Abstract

The goal of this teaching case study is to demonstrate the novel use of (99m)Tc-HMPAO-labeled white blood cells (WBCs) in diagnosing chronic recurrent multifocal osteomyelitis (CRMO). (99m)Tc-HMPAO-labeled white blood cells were utilized to diagnose CRMO. Classically, CRMO is evaluated scintigraphically using (99m)Tc-methylene diphosphonate/hydroxymethylene diphosphonate. (99m)Tc-HMPAO-labeled WBCs were chosen over (111)In-labeled WBCs because of the former's improved imaging characteristics and decreased radiation dose. (99m)Tc-HMPAO-labeled WBCs were successful in diagnosing CRMO. (99m)Tc-HMPAO-labeled WBC scanning is specific for the diagnosis of CRMO.

摘要

本教学案例研究的目的是展示（99m）锝-六甲基丙烯胺肟标记的白细胞（WBC）在诊断慢性复发性多灶性骨髓炎（CRMO）中的新用途。（99m）锝-六甲基丙烯胺肟标记的白细胞被用于诊断CRMO。传统上，CRMO通过（99m）锝-亚甲基二膦酸盐/羟亚甲基二膦酸盐进行闪烁显像评估。选择（99m）锝-六甲基丙烯胺肟标记的白细胞而非（111）铟标记的白细胞，是因为前者具有更好的成像特性且辐射剂量更低。（99m）锝-六甲基丙烯胺肟标记的白细胞成功诊断了CRMO。（99m）锝-六甲基丙烯胺肟标记的白细胞扫描对CRMO的诊断具有特异性。