局灶节段性肾小球硬化症中的通透性因素
Permeability factors in focal and segmental glomerulosclerosis.
作者信息
Reiser Jochen, Nast Cynthia C, Alachkar Nada
机构信息
Department of Medicine, Rush University School of Medicine, Chicago, IL; Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.
Department of Medicine, Rush University School of Medicine, Chicago, IL; Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.
出版信息
Adv Chronic Kidney Dis. 2014 Sep;21(5):417-21. doi: 10.1053/j.ackd.2014.05.010.
Focal and segmental glomerulosclerosis (FSGS) represents a group of glomerular disorders, identified on kidney biopsy, that progress in the histopathologic pattern of sclerosis in parts of some glomeruli. Damage to podocytes usually marks the beginning of the disease, most evident in primary FSGS. In addition to genetic predisposition, there are many acquired causes that disturb normal podocyte homeostasis and allow for the development of FSGS. The aim of this review was to summarize recent findings of the most relevant circulating permeability factors that may serve as biomarkers of active primary idiopathic FSGS and aid in the diagnosis and prediction of recurrent FSGS after kidney transplantation.
局灶节段性肾小球硬化（FSGS）是一组经肾活检确诊的肾小球疾病，其特征为部分肾小球出现硬化的组织病理学模式。足细胞损伤通常是该疾病的起始标志，在原发性FSGS中最为明显。除了遗传易感性外，还有许多后天因素会扰乱正常的足细胞内环境稳定，从而导致FSGS的发生。本综述的目的是总结近期有关最相关循环通透性因子的研究结果，这些因子可能作为活动性原发性特发性FSGS的生物标志物，并有助于肾移植后复发性FSGS的诊断和预测。
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