过敏与血液系统恶性肿瘤风险：关联与机制

Allergy and risk of hematologic malignancies: associations and mechanisms.

作者信息

Musolino C, Allegra A, Minciullo P L, Gangemi S

机构信息

Division of Hematology, Department of General Surgery and Oncology, University of Messina, Messina, Italy.

出版信息

Leuk Res. 2014 Oct;38(10):1137-44. doi: 10.1016/j.leukres.2014.08.004. Epub 2014 Aug 12.

DOI:10.1016/j.leukres.2014.08.004

PMID:25171954

Abstract

Increasing evidence indicates that a dysregulated immune system, as the one found in allergic disorders, can affect survival of tumor cells. A possible association between allergies and risk of hematologic malignancies has been examined in several epidemiological studies; however, results were not always consistent. The aim of this review is to report the preclinical and clinical data, which support a correlation between allergy and hematologic neoplasms. Immune system modulation could represent a powerful tool in the prevention and treatment of hematologic malignancies.

摘要

越来越多的证据表明，免疫系统失调，如在过敏性疾病中发现的那样，会影响肿瘤细胞的存活。几项流行病学研究已经探讨了过敏与血液系统恶性肿瘤风险之间的可能关联；然而，结果并不总是一致的。本综述的目的是报告支持过敏与血液系统肿瘤之间存在关联的临床前和临床数据。免疫系统调节可能是预防和治疗血液系统恶性肿瘤的有力工具。