School of Chemistry and Manchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Manchester Pharmacy School, University of Manchester, Manchester, UK.
Trends Biotechnol. 2014 Oct;32(10):538-48. doi: 10.1016/j.tibtech.2014.08.003. Epub 2014 Aug 29.
Breath-based metabolomics (breathomics) is an exciting developing area of biotechnology that centers on the capture, identification, and quantification of volatile organic compound (VOC) patterns in human breath and their utilization as tools in the diagnosis of a broad spectrum of medical problems. With the age of personalized medicines demanding rapid bespoke diagnosis and treatment, this area of molecular diagnostics is beginning to see an upsurge in biotechnological advancement. Here, we discuss recent improvements and directions in the development of breath VOC analysis and diagnosis platforms that offer the potential for disease biomarker discovery and disease prognosis.
呼吸代谢组学(breathomics)是生物技术中一个令人兴奋的新兴领域,其核心是捕捉、识别和定量分析人体呼吸中的挥发性有机化合物(VOC)模式,并将其用作诊断广泛医疗问题的工具。随着个性化医疗时代要求快速定制诊断和治疗,分子诊断领域开始看到生物技术的快速发展。在这里,我们讨论了呼吸 VOC 分析和诊断平台的最新进展和发展方向,这些平台为疾病生物标志物发现和疾病预后提供了潜力。