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[神经内分泌功能测试在抑郁症鉴别诊断中的效用]

[Usefulness of neuroendocrine function tests in the differential diagnosis of depression].

作者信息

Cervera S

机构信息

Departamento de Psiquiatría y Psicología Médica, Facultad de Medicina, Universidad de Navarra, Pamplona, España.

出版信息

Rev Esp Fisiol. 1989;45 Suppl:279-87.

PMID:2518335
Abstract

In order to find the correlation between dexamethasone suppression test (DST) and TSH response to TRH in the differential diagnosis of subtypes of depression, and to evaluate the possible relationship between Hypothalamic-Pituitary-Adreno-cortisol axis, Hypothalamic-Pituitary-Thyroid axis function, psychopathological symptoms, and the possible influence of age and sex, 107 depressed patients were studied. The relationship between both tests (DST and THS response to TRH) and the subtypes of depression was unspecific. The results did not show psychopathologic differences between depression subgroups. DST appeared to be a good marker for the "state" of illness, whereas TSH was better as a predictor for the outcome.

摘要

为了探讨地塞米松抑制试验(DST)与促甲状腺激素(TSH)对促甲状腺激素释放激素(TRH)反应之间的相关性,以用于抑郁症亚型的鉴别诊断,并评估下丘脑 - 垂体 - 肾上腺 - 皮质醇轴、下丘脑 - 垂体 - 甲状腺轴功能、精神病理症状之间可能存在的关系,以及年龄和性别的可能影响,我们对107例抑郁症患者进行了研究。两种试验(DST和TSH对TRH的反应)与抑郁症亚型之间的关系不具有特异性。结果未显示抑郁症亚组之间存在精神病理差异。DST似乎是疾病“状态”的良好标志物,而TSH作为预后预测指标则更佳。

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