冠心病中血管紧张素转换酶（ACE）基因I/D多态性和白细胞介素-4基因内含子3可变数目串联重复序列（VNTR）多态性的评估。

The evaluation of angiotensin-converting enzyme (ACE) gene I/D and IL-4 gene intron 3 VNTR polymorphisms in coronary artery disease.

作者信息

Basol Nursah, Celik Atac, Karakus Nevin, Ozturk Sibel Demir, Yigit Serbulent

机构信息

Gaziosmanpasa University, Faculty of Medicine, Department of Emergency Medicine, Tokat, Turkey

Gaziosmanpasa University, Faculty of Medicine, Department of Cardiology, Tokat, Turkey.

出版信息

In Vivo. 2014 Sep-Oct;28(5):983-7.

PMID:25189918

Abstract

BACKGROUND/AIM: Genetic polymorphism is a strong risk factor for coronary artery disease (CAD). In the present study, our aim was to evaluate angiotensin-converting enzyme (ACE) gene I/D polymorphism and interleukin-4 (IL-4) gene Intron 3 variable number of tandem repeat (VNTR) polymorphism in CAD.

MATERIALS AND METHODS

One hundred and twenty-four CAD patients and one hundred and twenty-three controls were enrolled. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) analyses.

RESULTS

The risk associated with inheriting the combined genotypes for the two polymorphisms were evaluated and it was found that the individuals who were P2P2-homozygous at IL-4 gene intron 3 VNTR and DD-homozygous at ACE gene I/D have a higher risk of developing CAD.

CONCLUSION

Although, there is no correlation between IL4 VNTR polymorphism and ACE gene polymorphism and CAD, there is a strong association between CAD and co-existence of IL-4 VNTR and ACE gene polymorphisms in the Turkish population.

摘要

背景/目的：基因多态性是冠状动脉疾病（CAD）的一个重要风险因素。在本研究中，我们的目的是评估CAD患者中血管紧张素转换酶（ACE）基因I/D多态性和白细胞介素-4（IL-4）基因内含子3可变串联重复序列（VNTR）多态性。