Department of Biosciences, University of Helsinki, Helsinki, Finland.
Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Science. 2014 Sep 5;345(6201):1130. doi: 10.1126/science.1252978.
Glykys et al. (Reports, 7 February 2014, p. 670) conclude that, rather than ion transporters, "local impermeant anions establish the neuronal chloride concentration" and thereby determine "the magnitude and direction of GABAAR currents at individual synapses." If this were possible, perpetual ion-motion machines could be constructed. The authors' conclusions conflict with basic thermodynamic principles.
格利克斯等人(报告,2014 年 2 月 7 日,第 670 页)得出结论,不是离子转运体,“局部不可渗透的阴离子决定神经元氯离子浓度”,从而决定“单个突触 GABAAR 电流的幅度和方向”。如果这是可能的,那么就可以构建永久性的离子运动机器。作者的结论与基本热力学原理相冲突。