CCR5δ32等位基因在丙型肝炎中的临床意义。
Clinical significance of the CCR5delta32 allele in hepatitis C.
作者信息
Morard Isabelle, Clément Sophie, Calmy Alexandra, Mangia Alessandra, Cerny Andrea, De Gottardi Andrea, Gorgievski Meri, Heim Markus, Malinverni Raffaele, Moradpour Darius, Müllhaupt Beat, Semela David, Pascarella Stéphanie, Bochud Pierre-Yves, Negro Franco
机构信息
Division of Gastroenterology and Hepatology, University Hospitals, Geneva, Switzerland.
Division of Clinical Pathology, University Hospitals, Geneva, Switzerland.
出版信息
PLoS One. 2014 Sep 5;9(9):e106424. doi: 10.1371/journal.pone.0106424. eCollection 2014.
BACKGROUND
The CCR5 receptor, expressed on Th1 cells, may influence clinical outcomes of HCV infection. We explored a possible link between a CCR5 32-base deletion (CCR5delta32), resulting in the expression of a non-functioning receptor, and clinical outcomes of HCV infection.
METHODS
CCR5 and HCV-related phenotypes were analysed in 1,290 chronically infected patients and 160 patients with spontaneous clearance.
RESULTS
Carriage of the CCR5delta32 allele was observed in 11% of spontaneous clearers compared to 17% of chronically infected patients (OR = 0.59, 95% CI interval 0.35-0.99, P = 0.047). Carriage of this allele also tended to be observed more frequently among patients with liver inflammation (19%) compared to those without inflammation (15%, OR = 1.38, 95% CI interval 0.99-1.95, P = 0.06). The CCR5delta32 was not associated with sustained virological response (P = 0.6), fibrosis stage (P = 0.8), or fibrosis progression rate (P = 0.4).
CONCLUSIONS
The CCR5delta32 allele appears to be associated with a decreased rate of spontaneous HCV eradication, but not with hepatitis progression or response to antiviral therapy.
背景
在Th1细胞上表达的CCR5受体可能会影响丙型肝炎病毒（HCV）感染的临床结局。我们探究了CCR5基因32碱基缺失（CCR5delta32）（导致无功能受体的表达）与HCV感染临床结局之间的潜在联系。
方法
对1290例慢性感染患者和160例自发清除病毒的患者的CCR5及HCV相关表型进行了分析。
结果
在160例自发清除病毒的患者中，11%存在CCR5delta32等位基因携带，而在1290例慢性感染患者中这一比例为17%（比值比[OR]=0.59，95%置信区间[CI]为0.35 - 0.99，P = 0.047）。与无肝脏炎症的患者（15%，OR = 1.38，95% CI为0.99 - 1.95，P = 0.06）相比，CCR5delta32等位基因携带在有肝脏炎症的患者中出现的频率也更高（19%）。CCR5delta32与持续病毒学应答（P = 0.6）、纤维化分期（P = 0.8）或纤维化进展率（P = 0.4）均无关联。
结论
CCR5delta32等位基因似乎与HCV自发清除率降低有关，但与肝炎进展或对抗病毒治疗的反应无关。
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