Inokuchi Jin-Ichi, Nagafuku Masakazu, Ohno Isao, Suzuki Akemi
Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
Biochim Biophys Acta. 2015 Jan;1851(1):98-106. doi: 10.1016/j.bbalip.2014.07.013. Epub 2014 Sep 3.
T cells compose a crucial part of the immune system and require activation. The first step of T cell activation is triggered by the movement of one of their surface molecules, known as T cell receptor, into localized regions of cell membrane known as lipid rafts. Molecules called gangliosides are known to be major components of lipid rafts, but their role in T-cell activation remains to be elucidated. This review summarizes recent findings that different types of T cells require distinct ganglioside types for the activation. Control of ganglioside expression would offer a strategy targeting for specific T-cell subpopulations to treat immune diseases. This article is part of a Special Issue entitled Linking transcription to physiology in lipodomics.
T细胞是免疫系统的关键组成部分，需要被激活。T细胞激活的第一步是由其一种表面分子（称为T细胞受体）移动到细胞膜的局部区域（称为脂筏）所触发。神经节苷脂分子被认为是脂筏的主要成分，但其在T细胞激活中的作用仍有待阐明。本综述总结了最近的研究发现，即不同类型的T细胞激活需要不同类型的神经节苷脂。控制神经节苷脂的表达将为治疗免疫疾病提供一种针对特定T细胞亚群的策略。本文是名为“脂质组学中转录与生理学的联系”特刊的一部分。
