利用监测、流行病学和最终结果（SEER）数据库对子宫内膜癌盆腔及腹主动脉旁转移进行的当代分析

Contemporary analysis of pelvic and para-aortic metastasis in endometrial cancer using the SEER registry.

作者信息

Katsoulakis Evangelia, Mattes Malcolm D, Rineer Justin M, Nabhani Thomas, Mourad Waleed F, Choi Kwang, Schreiber David

机构信息

Department of Radiation Oncology, New York Methodist Hospital, New York, NY, USA.

出版信息

Int J Gynaecol Obstet. 2014 Dec;127(3):293-6. doi: 10.1016/j.ijgo.2014.06.022. Epub 2014 Aug 13.

DOI:10.1016/j.ijgo.2014.06.022

PMID:25194213

Abstract

OBJECTIVE

To determine the incidence of regional lymph node involvement for early-stage endometrial cancer by using the Surveillance, Epidemiology, and End Results (SEER) registry.

METHODS

In a retrospective study, data were analyzed from patients who were diagnosed with stage IA-IIB endometrioid adenocarcinoma and were treated between 1998 and 2003. The incidence of pelvic and para-aortic lymph node involvement was determined.

RESULTS

Data were analyzed from 4052 patients. Incidences of pelvic and para-aortic lymph node metastases were: 1% and 0% in stage IA, grade 1 disease; 2% and 0% in IA, grade 2; 2% and 1% in IA, grade 3; 2% and 0% in IB, grade 1; 3% and 1% in IB, grade 2; 3% and 2% in IB, grade 3; 7% and 3% in IC, grade 1; 8% and 5% in IC, grade 2; 12% and 8% in IC, grade 3; 7% and 3% in IIA, grade 1; 10% and 4% in IIA, grade 2; 10% and 5% in IIA, grade 3; 8% and 4% in IIB, grade 1; 13% and 8% in IIB, grade 2; and 19% and 12% in IIB, grade 3.

CONCLUSION

Incidences of pelvic and para-aortic metastases were lower than previously reported. Patients at higher stages and grades had a 10% or higher risk of lymph node involvement and might benefit from aggressive therapy.

摘要

目的

利用监测、流行病学和最终结果（SEER）登记系统确定早期子宫内膜癌区域淋巴结受累的发生率。

方法

在一项回顾性研究中，分析了1998年至2003年间被诊断为IA-IIB期子宫内膜样腺癌并接受治疗的患者的数据。确定盆腔和腹主动脉旁淋巴结受累的发生率。

结果

对4052例患者的数据进行了分析。盆腔和腹主动脉旁淋巴结转移的发生率分别为：IA期1级疾病为1%和0%；IA期2级为2%和0%；IA期3级为2%和1%；IB期1级为2%和0%；IB期2级为3%和1%；IB期3级为3%和2%；IC期1级为7%和3%；IC期2级为8%和5%；IC期3级为12%和8%；IIA期1级为7%和3%；IIA期2级为10%和4%；IIA期3级为10%和5%；IIB期1级为8%和4%；IIB期2级为13%和8%；IIB期3级为19%和12%。