Ioniţă E, Lupulescu E, Alexandrescu V, Maţepiuc M, Constantinescu C, Creţescu L, Velea L
Arch Roum Pathol Exp Microbiol. 1989 Jul-Sep;48(3):265-73.
The antibody responses induced by the split influenza vaccine adsorbed on aluminium phosphate and the corresponding, nonadsorbed vaccine, both prepared in the Cantacuzino Institute, were studied in subjects belonging to three different age groups: 3-6, 10-15 and over 60 years of age, respectively. In all age groups the immunogenicity of the two vaccine preparations was similar, being uninfluenced by the level of preexisting antibodies. The immunogenicity of both vaccines was similar even in children considered to be non-primed. There were no differences in the persistence and specificity of antibodies induced by the two vaccines. No significant enhancement of the immunogenicity by aluminium phosphate was observed.
对坎塔库齐诺研究所制备的吸附于磷酸铝的裂解流感疫苗和相应的未吸附疫苗所诱导的抗体反应，在分别属于三个不同年龄组的受试者中进行了研究：3 - 6岁、10 - 15岁和60岁以上。在所有年龄组中，两种疫苗制剂的免疫原性相似，不受预先存在抗体水平的影响。即使在被认为未接种过疫苗的儿童中，两种疫苗的免疫原性也相似。两种疫苗诱导的抗体在持久性和特异性方面没有差异。未观察到磷酸铝对免疫原性有显著增强作用。
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