An Enantioselective Synthesis of a MEM-Protected Aetheramide A Derivative.
作者信息
Ghosh Arun K, Rao Kalapala Venkateswara, Akasapu Siddhartha
机构信息
Department of Chemistry and Department of Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States.
出版信息
Tetrahedron Lett. 2014 Sep 10;55(37):5191-5194. doi: 10.1016/j.tetlet.2014.07.077.
Abstract
Aetheramides A and B are very potent anti-HIV agents. An enantioselective synthesis of a MEM-protected aetheramide A derivative is described. The synthesis was accomplished in a convergent and stereoselective manner. The key reactions involved asymmetric dihydroxylation, asymmetric allylation, asymmetric -aldol reactions and asymmetric hydrogenation.
摘要
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