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先天性泪囊膨出的产前诊断及围产期结局:一项大型病例系列研究

Prenatal diagnosis and perinatal outcome of congenital dacryocystocele: a large case series.

作者信息

Li Sheng-li, Luo Guo-yang, Tian Xiao-xian, Yu Rong, Norwitz Errol R, Qin Feng-zhen, Wen Hua-Xuan, Bi Jing-ru, Lin Xiao-ying, Zhong Xiao-hong

机构信息

Department of Ultrasound, Shenzhen Maternity and Child Healthcare Hospital, Affiliated to Southern Medical University, Shenzhen, Guangdong, China.

出版信息

Prenat Diagn. 2015 Feb;35(2):103-7. doi: 10.1002/pd.4494. Epub 2014 Oct 2.

DOI:10.1002/pd.4494
PMID:25201035
Abstract

OBJECTIVE

To describe the incidence, prenatal diagnosis, and perinatal outcome in fetuses with congenital dacryocystocele.

METHODS

All cases of congenital dacryocystocele diagnosed by prenatal ultrasound were identified using an established perinatal database. Prenatal ultrasound images were reviewed, and perinatal outcome was abstracted from the medical records. The correlation between the cyst size, gestational age, and prenatal and neonatal outcome was analyzed.

RESULTS

The overall incidence of fetal dacryocystocele was 0.016% (75/456,202). Fifty-three cases (70.7%) had unilateral, and 22 (29.3%) had bilateral lesions. Lesions were seen more commonly among female fetuses with a female : male ratio 1.48 : 1. The average diameter of cysts size was 6.9 ± 1.9 mm (3.3-11 mm). There was a direct correlation between cyst size and gestational age. Among the 75 cases, 8 were lost to follow-up, 3 underwent elective termination of pregnancy. 58 resolved spontaneously before birth, and 6 were confirmed at birth. Two developed neonatal infection requiring antibiotic treatment. All 6 cases confirmed at birth resolved without surgical resection.

CONCLUSIONS

Congenital dacryocystocele can be diagnosed by prenatal ultrasound. Such lesions typically resolve spontaneously in utero or in the early neonatal period. Thus, it should be considered as a developmental variant rather than a structural birth defect.

摘要

目的

描述先天性泪囊膨出胎儿的发病率、产前诊断及围产期结局。

方法

使用已建立的围产期数据库确定所有经产前超声诊断为先天性泪囊膨出的病例。回顾产前超声图像,并从病历中提取围产期结局。分析囊肿大小、孕周与产前及新生儿结局之间的相关性。

结果

胎儿泪囊膨出的总体发病率为0.016%(75/456,202)。53例(70.7%)为单侧病变,22例(29.3%)为双侧病变。病变在女胎中更常见,男女比例为1.48∶1。囊肿平均直径为6.9±1.9mm(3.3 - 11mm)。囊肿大小与孕周呈直接相关。75例中,8例失访,3例接受选择性终止妊娠。58例在出生前自行消退,6例在出生时得到证实。2例发生新生儿感染需要抗生素治疗。出生时确诊的所有6例均未行手术切除即痊愈。

结论

先天性泪囊膨出可通过产前超声诊断。此类病变通常在子宫内或新生儿早期自行消退。因此,应将其视为一种发育变异而非结构性出生缺陷。

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