ZNF217 表达在胃癌中的预后意义。
Prognostic significance of ZNF217 expression in gastric carcinoma.
机构信息
Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
Department of Surgery, Jikei University School of Medicine, Tokyo, Japan.
出版信息
Anticancer Res. 2014 Sep;34(9):4813-7.
BACKGROUND
The zinc finger protein ZNF217 is a candidate oncogene in breast cancer and ovarian clear cell cancer. The purpose of the present study was to clarify the significance of this protein's expression in gastric carcinoma and to evaluate the outcome of these patients.
MATERIALS AND METHODS
Using paraffin-embedded specimens from 84 patients with gastric cancer, ZNF217 protein was detected using an anti-ZNF217 goat polyclonal antibody. We evaluated the ZNF217 protein expression in relation to patient outcome and clinicopathological parameters.
RESULTS
The ZNF217 protein was expressed in 34 (40.5%) tumor sections. Patients with ZNF217-negative tumors had better relapse-free survival (RFS) and overall survival (OS) than those with ZNF217-positive tumors by the log-rank test. Notably, multivariate analysis indicated that ZNF217 was an independent prognostic factor for RFS.
CONCLUSION
ZNF217 expression seems to be a novel prognostic biomarker in gastric cancer.
背景
锌指蛋白 ZNF217 是乳腺癌和卵巢透明细胞癌的候选癌基因。本研究旨在阐明该蛋白在胃癌中的表达意义，并评估这些患者的预后。
材料和方法
使用来自 84 例胃癌患者的石蜡包埋标本，使用抗 ZNF217 山羊多克隆抗体检测 ZNF217 蛋白。我们评估了 ZNF217 蛋白表达与患者预后和临床病理参数的关系。
结果
ZNF217 蛋白在 34 个（40.5%）肿瘤切片中表达。通过对数秩检验，ZNF217 阴性肿瘤患者的无复发生存率（RFS）和总生存率（OS）明显优于 ZNF217 阳性肿瘤患者。值得注意的是，多变量分析表明 ZNF217 是 RFS 的独立预后因素。
结论
ZNF217 表达似乎是胃癌的一种新的预后生物标志物。
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