钌催化的区域选择性烯丙基三氟甲硫基化反应。

Ruthenium-catalyzed regioselective allylic trifluoromethylthiolation reaction.

作者信息

Ye Ke-Yin, Zhang Xiao, Dai Li-Xin, You Shu-Li

机构信息

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.

出版信息

J Org Chem. 2014 Dec 19;79(24):12106-10. doi: 10.1021/jo5019393. Epub 2014 Sep 18.

DOI:10.1021/jo5019393

PMID:25203498

Abstract

An efficient Ru-catalyzed regioselective allylic trifluoromethylthiolation reaction of allylic carbonates was developed. The linear allylic trifluoromethyl thioethers were obtained in 52-91% yields. Mechanistic investigation revealed that this reaction proceeds via a double allylic trifluoromethylthiolation sequence.

摘要

开发了一种高效的钌催化的碳酸烯丙酯区域选择性烯丙基三氟甲硫基化反应。线性烯丙基三氟甲硫醚的产率为52-91%。机理研究表明，该反应通过双烯丙基三氟甲硫基化序列进行。