钙结合蛋白 D28K 在雌激素治疗帕金森病中的作用。
Role of calbindin-D28K in estrogen treatment for Parkinson's disease.
机构信息
Department of Neurobiology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China ; Department of Neurology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China ; Department of Neurology, Funing County People's Hospital, Yancheng 224400, Jiangsu Province, China.
Department of Neurobiology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China.
出版信息
Neural Regen Res. 2013 Mar 15;8(8):702-7. doi: 10.3969/j.issn.1673-5374.2013.08.004.
Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system. The present study established a Parkinson's disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine. The mice were subjected to 17β estradiol injection into the lateral ventricle. Immunofluorescence double staining showed that estrogen increased tyrosine hydroxylase and calbindin-D28K expression and co-expression in dopaminergic neurons of midbrain substantia nigra pars compacta of model mice. Behavior experiments showed that estrogen improved swimming and hanging behaviors in this mouse model of Parkinson's disease.
研究表明，雌激素对黑质纹状体系统具有神经保护作用。本研究通过腹腔注射 1-甲基-4-苯基-1,2,3,6-四氢吡啶在 C57BL/6 小鼠中建立帕金森病模型。然后将小鼠进行侧脑室注射 17β 雌二醇。免疫荧光双重染色显示，雌激素增加了模型小鼠中脑黑质致密部多巴胺能神经元中酪氨酸羟化酶和钙结合蛋白-D28K 的表达和共表达。行为学实验表明，雌激素改善了帕金森病模型小鼠的游泳和悬挂行为。
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