结构生物学：核糖体的新发现 - Suppr

Structural biology: Ribosome revelations.

作者信息

Olivier Nelson B

机构信息

Innovative Medicines and Early Development Unit, AstraZeneca Pharmaceuticals, Cambridge Science Park, Cambridge CB4 0FZ, UK.

出版信息

Nature. 2014 Sep 25;513(7519):491-2. doi: 10.1038/nature13747. Epub 2014 Sep 10.

DOI:10.1038/nature13747

PMID:25209662

Abstract

摘要

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Structural basis for the inhibition of the eukaryotic ribosome.

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Discovery of natural products possessing selective eukaryotic readthrough activity: 3-epi-deoxynegamycin and its leucine adduct.

ChemMedChem. 2014 Oct;9(10):2233-7. doi: 10.1002/cmdc.201402208. Epub 2014 Jul 9.

4'-O-substitutions determine selectivity of aminoglycoside antibiotics.

Nat Commun. 2014;5:3112. doi: 10.1038/ncomms4112.

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles.

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Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.

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The A-Z of bacterial translation inhibitors.

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The use of ribosomal crystal structures in antibiotic drug design.

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Structures of the bacterial ribosome at 3.5 A resolution.

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Structural biology: Ribosome revelations.

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