Calik Mustafa, Oguz Elif, Sarikaya Suna, Kocaturk Ozcan, Koca Bulent, Gungor Hatice Eke, Aksoy Nurten, Yoldas Tahır Kurtulus, Iscan Akin
Department of Pediatric Neurology, Harran University School of Medicine, Sanliurfa, Turkey.
Department of Pharmacology, Harran University School of Medicine, Sanliurfa, Turkey.
Epilepsy Res. 2014 Nov;108(9):1591-6. doi: 10.1016/j.eplepsyres.2014.08.007. Epub 2014 Sep 2.
Epilepsy is the most common chronic neurological illness in childhood and adolescence. The aim of this study was to investigate paraoxonase and arylesterase activities along with oxidative status parameters in children with intractable epilepsy. The study comprised 42 subjects with intractable epilepsy and a control group of 35 healthy subjects. Serum paraoxonase and arylesterase activities, and lipid hydroperoxide levels were determined. All paraoxonase and arylesterase activities were significantly lower in the intractable epilepsy subjects than in the controls (P<0.001), whereas lipid hydroperoxide levels were significantly higher (P<0.05). In conclusion, paraoxonase and arylesterase activities were decreased and the lipid hydroperoxide level was increased in patients with intractable epilepsy. These results showed that intractable epilepsy subjects may be more prone to the development of atherosclerosis.
癫痫是儿童和青少年时期最常见的慢性神经疾病。本研究的目的是调查难治性癫痫患儿的对氧磷酶和芳基酯酶活性以及氧化状态参数。该研究包括42名难治性癫痫患者和35名健康受试者组成的对照组。测定了血清对氧磷酶和芳基酯酶活性以及脂质过氧化氢水平。难治性癫痫患者的所有对氧磷酶和芳基酯酶活性均显著低于对照组（P<0.001），而脂质过氧化氢水平显著更高（P<0.05）。总之，难治性癫痫患者的对氧磷酶和芳基酯酶活性降低，脂质过氧化氢水平升高。这些结果表明，难治性癫痫患者可能更容易发生动脉粥样硬化。
