粒细胞集落刺激因子和粒细胞-巨噬细胞集落刺激因子在早产儿感染管理中的作用：最新进展

Role of G-CSF GM-CSF in the management of infections in preterm newborns: an update.

作者信息

Castagnola Elio, Dufour Carlo

机构信息

Istituto Giannina Gaslini Genoa Italy.

出版信息

Early Hum Dev. 2014 Sep;90 Suppl 2:S15-7. doi: 10.1016/S0378-3782(14)50005-9.

DOI:10.1016/S0378-3782(14)50005-9

PMID:25220119

Abstract

Neutropenia (definable as an absolute granulocyte count <1,000/μL in neonates) is a relatively frequent condition in small for gestational age and/or low birth weight neonates. Colony stimulating factors (CSF), namely granulocyte- (G-CSF) and granulocyte-macrophage- (GM-CSF) CSF, have been proposed for prophylaxis and therapy of severe infections in this condition. Available data do not support the use of these substances for prophylaxis of infections in the presence of neutropenia. On the contrary, there might be space for their use, mainly for G-CSF, in case of severe infectious complications in severely neutropenic neonates (absolute polymorphonuclear neutrophil count <500/μL) and/or in the presence of specific hematological diseases causing neutropenia.

摘要

中性粒细胞减少症（在新生儿中定义为绝对粒细胞计数<1000/μL）在小于胎龄和/或低出生体重的新生儿中是一种相对常见的情况。集落刺激因子（CSF），即粒细胞集落刺激因子（G-CSF）和粒细胞-巨噬细胞集落刺激因子（GM-CSF），已被提议用于预防和治疗这种情况下的严重感染。现有数据不支持在存在中性粒细胞减少症时使用这些物质来预防感染。相反，在严重中性粒细胞减少的新生儿（绝对多形核中性粒细胞计数<500/μL）出现严重感染并发症和/或存在导致中性粒细胞减少的特定血液疾病的情况下，它们（主要是G-CSF）可能有使用的空间。