Capasso Letizia, Borrelli Angela Carla, Ferrara Teresa, Coppola Clara, Cerullo Julia, Izzo Federica, Caiazza Roberta, Lama Silvia, Raimondi Francesco
Section of Pediatrics, Universitá degli Studi di Napoli Federico II, Naples, Italy.
Section of Pediatrics, Universitá degli Studi di Napoli Federico II, Naples, Italy.
Early Hum Dev. 2014 Sep;90 Suppl 2:S47-9. doi: 10.1016/S0378-3782(14)50013-8.
Systemic infection is a major cause of mortality and morbidity among premature neonates. In this fragile population, the immaturity of the innate immune response relates inversely to gestational age and is one of the determinants of susceptibility to infections. Antibiotic therapy, even when appropriately and timely instituted, may fail to prevent death or significant sequelae. The quest for additional strategies is still open; in this scenario, the supplementation with exogenous immunoglobulins represents an attractive additional strategy of defence. As current data are conflicting, we provide a critical appraisal with a focus on IgM enriched immunoglobulins preparations.
全身感染是早产新生儿死亡和发病的主要原因。在这个脆弱的群体中，先天免疫反应的不成熟与胎龄呈负相关，是易感染的决定因素之一。抗生素治疗即使适当且及时进行，也可能无法预防死亡或严重后遗症。寻求其他策略的探索仍在继续；在这种情况下，补充外源性免疫球蛋白是一种有吸引力的额外防御策略。由于目前的数据相互矛盾，我们重点对富含IgM的免疫球蛋白制剂进行了批判性评估。
