Arolt Volker, Ambrée Oliver
Department of Psychiatry, University of Münster, Münster, Germany.
Mod Trends Pharmacopsychiatry. 2013;28:100-16. doi: 10.1159/000343972. Epub 2013 Feb 27.
Throughout the last 20 years, numerous studies have indicated pro-inflammatory activity in patients with an acute schizophrenic episode. In this report, the most relevant findings concerning the cytokine systems in schizophrenia are demonstrated, together with recent studies on gene expression. Findings in humans are supplemented by observations from rodent models of schizophrenia. Furthermore, the current state of both neuroleptic and anti-inflammatory compounds on the immune system is reported, together with clinical data on the effects of anti-inflammatory medications on the course of the acute illness in patients with schizophrenia.
在过去20年中，大量研究表明急性精神分裂症发作患者存在促炎活性。在本报告中，展示了与精神分裂症细胞因子系统相关的最关键发现，以及近期关于基因表达的研究。来自精神分裂症啮齿动物模型的观察结果补充了人类研究的发现。此外，还报告了抗精神病药物和抗炎化合物对免疫系统的当前作用情况，以及抗炎药物对精神分裂症患者急性病程影响的临床数据。
