非甾体抗炎药与炎症性肠病：病理生理学及临床关联

Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: pathophysiology and clinical associations.

作者信息

Habib Ibrahim, Mazulis Andrew, Roginsky Grigory, Ehrenpreis Eli D

机构信息

*Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, Illinois; †Division of Gastroenterology, Department of Medicine, NorthShore University HealthSystem, Evanston, Illinois; and ‡Center for the Study of Complex Diseases, NorthShore University HealthSystem, Evanston, Illinois.

出版信息

Inflamm Bowel Dis. 2014 Dec;20(12):2493-502. doi: 10.1097/MIB.0000000000000165.

DOI:10.1097/MIB.0000000000000165

PMID:25230166

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) produce significant gastrointestinal (GI) adverse events. Laboratory and clinical studies suggest that NSAIDs have the potential to trigger the onset or relapse of inflammatory bowel disease. In this review, the currently available information on the mechanism of action of NSAID injury of the GI tract and the pathophysiology of GI effects of NSAIDs, including immune dysregulation will be assessed. A detailed description of NSAID effects on individual GI organs will be discussed. This is followed by a MEDLINE review of clinical literature on the relationship between NSAID ingestion and the development and worsening of inflammatory bowel disease.

摘要

非甾体抗炎药（NSAIDs）会引发严重的胃肠道（GI）不良事件。实验室和临床研究表明，NSAIDs有可能引发炎症性肠病的发作或复发。在本综述中，将评估目前有关NSAIDs对胃肠道损伤的作用机制以及NSAIDs胃肠道效应的病理生理学（包括免疫失调）的现有信息。将讨论NSAIDs对各个胃肠道器官影响的详细描述。随后是对关于摄入NSAIDs与炎症性肠病的发生和恶化之间关系的临床文献的医学文献数据库（MEDLINE）综述。