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局部麻醉下经皮肾冷冻消融术的可行性。

The feasibility of percutaneous renal cryoablation under local anaesthesia.

作者信息

de Kerviler Eric, de Margerie-Mellon Constance, Coffin Alexandre, Legrand Guillaume, Resche-Rigon Matthieu, Ploussard Guillaume, Meria Paul, Mongiat-Artus Pierre, Desgrandchamps François, de Bazelaire Cédric

机构信息

Service de Radiologie, INSERM UMR_S1165, Hôpital Saint-Louis, Assistance Publique, Hôpitaux de Paris, Université Paris 7 Denis Diderot, Sorbonne Paris-Cité, 1 Avenue Claude Vellefaux, 75010, Paris, France,

出版信息

Cardiovasc Intervent Radiol. 2015 Jun;38(3):672-7. doi: 10.1007/s00270-014-0995-x. Epub 2014 Sep 18.

Abstract

OBJECTIVES

The aim of this study was to evaluate the feasibility of cryoablation of renal tumours without sedation.

MATERIALS AND METHODS

We prospectively evaluated 149 computed tomography-guided renal cryoablation procedures that were performed at our institution between 2009 and 2013. The patients received only 1 g of IV paracetamol prior to the procedure; intraprocedural, local anaesthesia was administered. We recorded the date and duration of the procedure, size and location of the tumour, number of cryoneedles used, need for dissection with saline or carbon dioxide and intraprocedural degree of pain, which was scored using an established visual analogue pain score (VAS) (0-10). Multivariate analysis was used to identify the associations between the recorded parameters and VAS.

RESULTS

An interventional radiologist and a technician could perform all procedures without the help of anaesthesiologists and with adequate analgesia. The pain level ranged from 0 to 8 (mean, 2.0). It did not correlate with the tumour size or with the number of cryoneedles. It was significantly greater when the ice ball involved renal cavities (p = .0033) and when carbon dioxide was used for dissection (p < .0001). Conversely, the team experience was positively correlated with lower pain levels (p = .0381).

CONCLUSION

This study demonstrates that the cryoablation of renal tumours is feasible by interventional radiologists alone using a combination of IV paracetamol and local anaesthesia.

摘要

目的

本研究旨在评估在无镇静情况下进行肾肿瘤冷冻消融术的可行性。

材料与方法

我们前瞻性地评估了2009年至2013年间在本机构进行的149例计算机断层扫描引导下的肾冷冻消融手术。患者在手术前仅接受1克静脉注射对乙酰氨基酚;术中给予局部麻醉。我们记录了手术日期和持续时间、肿瘤大小和位置、使用的冷冻针数量、是否需要用盐水或二氧化碳进行分离以及术中疼痛程度,疼痛程度使用既定的视觉模拟疼痛评分(VAS)(0 - 10)进行评分。采用多变量分析来确定记录参数与VAS之间的关联。

结果

一名介入放射科医生和一名技术人员可以在没有麻醉医生帮助且镇痛充分的情况下完成所有手术。疼痛程度范围为0至8(平均为2.0)。它与肿瘤大小或冷冻针数量无关。当冰球累及肾腔时(p = 0.0033)以及使用二氧化碳进行分离时(p < 0.0001),疼痛程度明显更高。相反,团队经验与较低的疼痛程度呈正相关(p = 0.0381)。

结论

本研究表明,介入放射科医生单独使用静脉注射对乙酰氨基酚和局部麻醉相结合的方法进行肾肿瘤冷冻消融术是可行的。

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