Sheehan S J, Rajah S M, Kester R C
Cardiac Research Unit, Killingbeck Hospital, Leeds, UK.
Biomaterials. 1989 Mar;10(2):75-9. doi: 10.1016/0142-9612(89)90034-3.
The effects of single- and four-stage preclotting methods on graft porosity and thrombogenicity were compared in two types of Dacron prosthesis. The single-stage method significantly reduced leakage of blood (P less than 0.001), but did not seal the grafts. The four-stage method rendered the grafts impermeable at the second step. Thrombogenicity was compared by perfusing preclotted grafts with fresh heparinized blood (containing 111In-labelled platelets) in an artificial circulation. Platelet deposition and consumption were significantly less in the four-stage method whilst platelet function remained unchanged during perfusion. We conclude that the four-stage technique is superior to standard preclotting methods by rendering knitted Dacron grafts impermeable and hypothrombogenic.
在两种类型的涤纶人工血管中比较了单阶段和四阶段预凝方法对移植物孔隙率和血栓形成性的影响。单阶段方法显著减少了血液渗漏（P<0.001），但未封闭移植物。四阶段方法在第二步使移植物变得不可渗透。通过在人工循环中用新鲜的肝素化血液（含有111铟标记的血小板）灌注预凝的移植物来比较血栓形成性。在四阶段方法中，血小板沉积和消耗显著减少，而在灌注过程中血小板功能保持不变。我们得出结论，四阶段技术通过使针织涤纶移植物不可渗透和低血栓形成性，优于标准的预凝方法。
