孕期及儿童早期的丙型肝炎病毒：当前认知与知识空白
Hepatitis C Virus in Pregnancy and Early Childhood: Current Understanding and Knowledge Deficits.
作者信息
Jhaveri Ravi, Swamy Geeta K
机构信息
Division of Pediatric Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine;
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.
出版信息
J Pediatric Infect Dis Soc. 2014 Sep;3 Suppl 1(Suppl 1):S13-8. doi: 10.1093/jpids/piu045.
Hepatitis C virus (HCV) is a well known cause of chronic liver disease in adults, but the burden of HCV in pregnant women and children is underappreciated. The leading route of HCV acquisition in children is vertical transmission. This review will discuss previous studies on the impact of HCV on pregnancy, risk factors for perinatal transmission, HCV transmission rates from mother to infant, what influence the virus has on the exposed or infected infant, and those areas where additional studies are required to advance our understanding of HCV pathogenesis during pregnancy. The rapid expansion of HCV treatment regimens free of interferon and ribavirin will expand future therapeutic opportunities for pregnant women and infected infants.
丙型肝炎病毒（HCV）是成人慢性肝病的常见病因，但HCV在孕妇和儿童中的负担尚未得到充分认识。儿童感染HCV的主要途径是垂直传播。本综述将讨论以往关于HCV对妊娠的影响、围产期传播的危险因素、母婴HCV传播率、该病毒对暴露或感染婴儿的影响，以及需要进一步研究以增进我们对妊娠期间HCV发病机制理解的领域。不含干扰素和利巴韦林的HCV治疗方案的迅速扩展将为孕妇和受感染婴儿带来更多未来治疗机会。
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