1例冯·希佩尔-林道病患者发生中枢神经系统转移的胰腺神经内分泌肿瘤：病例报告及文献复习

Metastatic pancreatic neuroendocrine tumor to the central nervous system in a patient with von Hippel-Lindau disease: A case report and literature review.

作者信息

Reynolds Matthew R, Crilly Shane M, Sweeney Kieron J, Farrell Michael, Rawluk Daniel

机构信息

Department of Neurological Surgery, Washington University in St. Louis , St. Louis, MO , USA.

出版信息

Br J Neurosurg. 2015 Apr;29(2):291-3. doi: 10.3109/02688697.2014.957650. Epub 2014 Sep 18.

DOI:10.3109/02688697.2014.957650

PMID:25232806

Abstract

Pancreatic neuroendocrine tumor (NET) is frequently encountered in patients with von Hippel-Lindau disease (VHL) and uncommonly metastasizes to the central nervous system. Here, we present the case of a VHL patient with symptomatic pancreatic NET metastases to both the cervical spinal cord and a preexisting brainstem hemangioblastoma (e.g., tumor- to-tumor metastasis).

摘要

胰腺神经内分泌肿瘤（NET）在冯·希佩尔-林道病（VHL）患者中经常出现，并且很少转移至中枢神经系统。在此，我们报告一例VHL患者，其胰腺NET出现症状性转移至颈脊髓和一个已存在的脑干血管母细胞瘤（即肿瘤至肿瘤转移）。